'A population-specific HTR2B stop codon predisposes to severe
impulsivity
Impulsivity, describing action without foresight, is an important
feature of several psychiatric diseases, suicidality and violent
behaviour. The complex origins of impulsivity hinder identification of
the genes influencing it and the diseases with which it is
associated.
Here we perform exon-focused sequencing of impulsive individuals in a
founder population, targeting fourteen genes belonging to the
serotonin and dopamine domain.
A stop codon in HTR2B was identified that is common (minor allele
frequency > 1%) but exclusive to Finnish people. Expression of the
gene in the human brain was assessed, as well as the molecular
functionality of the stop codon, which was associated with psychiatric
diseases marked by impulsivity in both population and family-based
analyses.
Knockout of Htr2b increased impulsive behaviours in mice, indicative
of predictive validity. Our study shows the potential for identifying
and tracing effects of rare alleles in complex behavioural phenotypes
using founder populations, and indicates a role for HTR2B in
impulsivity.'
The Study: John R. Kelsoe in Nature, Volume: 468, Pages: 1049–1050,
Date published: 23 December 2010, DOI: doi:10.1038/4681049a, Published
online 22 December 2010
Minun Englannin kieli on yhtä ruosteinen niin kuin naapurin Lada,
mutta kai tästä jotain 'tolokkua voi mulukata' ;D
IT IS THE MIND OF A MAN
that directs what the body of a man do,
NOT THE GENES
by Matti E Simonaho, January 21 2011
One evening, I saw how a person suddenly went berserk, broke
everything around him screaming at the same time like an animal. A
little later, he sat smiling and chatting just like nothing had
happened - with the film director who had directed the movie.
The Study 'A population-specific HTR2B stop codon predisposes to
severe impulsivity"
John R. Kelsoe, Nature, Volume: 468, Pages: 1049–1050, Date published:
23 December 2010, DOI: doi:10.1038/4681049a, Published online 22
December 2010"
Let's compare 'the stop codon in HTR2B' that according to The Study is
'exclusive to Finnish people' and is the source of 'Impulsivity,
action without foresight, feature of several psychiatric diseases,
suicidality and violent behaviour', with America.
We use the data of Finnish violent behavior domestic and abroad
between 1960 - 2010, and compare the data with the violent behavior of
Americans, domestic and abroad during the same period of time.
The data show, that violent behaviour agaist themself and/or agaist
people abroad in both countries, have nothing at all to do with gens;
It is the quality of the mind of a man that directs what the body of a
man do -- in large scale the intelligence/educational level of the
leaders of a country directs what the people of a country do --, not
the genes.
Best regards from Finland,
a country and people,
who never have started a war,
but are victims of war(s),
like the people of America are.
M0D1C2C3LXX4V5I
'This is the book of the generations of Adam. In the day that God
created man, in the likeness of God made he him; Male and female
created he them; and blessed them, and called their name Adam, in the
day when they were created.' 1 Moses 5:1-2 (LXX V:I, Septuaginta 5:1)
If i had been given $1 for each thought, i would be a millionair by
now, however; Every good thought from a pure mind is A Lords prayer,
and it don't cost anything, because, every such thought is A Service
of God, while a bad thought from an unpure mind, may cost everything,
and such thought is not service of God.